Evolution of Radiotherapy: High-precision Radiotherapy

Cellular signalling effects in high precision radiotherapy.

Radiotherapy is commonly planned on the basis of physical dose received by the tumour and surrounding normal tissue, with margins added to address the possibility of geometric miss. However, recent experimental evidence suggests that intercellular signalling results in a given cell's survival also depending on the dose received by neighbouring cells. A model of radiation-induced cell killing an...

Dose distributions of high-precision radiotherapy treatment: A comparison between the CyberKnife and TrueBeam systems

Background: Several high-precision stereotactic radiation therapy modalities are currently used in clinical settings. We aimed to evaluate whether the CyberKnife (CK) or TrueBeam (TB) radiation treatment systems were more appropriate for treating targets of various morphologies according to the physical properties of each device.  Materials and Methods: Spheres (diameter = 5–50 mm), as well as ...

High Precision Radiotherapy Techniques in the Management of Brain Tumours: Evolution and Clinical Experience

Precision Radiotherapy for Small Animal Research

Preclinical research using well characterized small animal models has provided tremendous benefits to medical research, enabling low cost, large scale trials with high statistical significance of observed effects. The goal of the Small Animal Radiation Research Platform (SARRP) is to make those models available for the development and evaluation of novel radiation therapies. SARRP demonstrates ...

Radiomics and radiogenomics for precision radiotherapy

Imaging plays an important role in the diagnosis and staging of cancer, as well as in radiation treatment planning and evaluation of therapeutic response. Recently, there has been significant interest in extracting quantitative information from clinical standard-of-care images, i.e. radiomics, in order to provide a more comprehensive characterization of image phenotypes of the tumor. A number o...